As part of our commitment to unparalleled scientific research – from discovery to invention – our scientists and postdoctoral research fellows are encouraged to be active members of the scientific community and have published papers in numerous peer-reviewed, thought-leading publications.
| DATE | June 30, 2026 |
| Title | Efficacy, safety, and immunogenicity of an Escherichia coli-produced nine-valent human papillomavirus vaccine: a multicentre, double-blind, randomised, controlled, phase 3 trial |
| Journal | The Lancet Infectious Diseases, 2026; |
| Authors | Hong-Xing Pan, Zhao-Feng Bi, Yu-Lin Jing, Shang-Ying Hu, Li Zhang, Kong-Xin Zhu, Kai Chu, Ying Hong, Shu-Fang Chang, Qin-Jing Pan, Xun Zhang, Jin-Bo Xu, Jie Tang, Dong-Ya Yuan, Hui Jiang, Chao Du, Guang Sun, Guo-Hua Zhong, Qi Chen, Li-Hui Wei, You-Lin Qiao, Shao-Wei Li, Ying-Ying Su, Qiu-Fen Zhang, Shou-Jie Huang, Fang-Hui Zhao, Wei-Jin Huang, Ting Wu, Jun Zhang, Ning-Shao Xia |
| DOI | https://doi.org/10.1016/S1473-3099(26)00221-5 |
| DATE | April 15, 2026 |
| Title | Immunogenicity and safety of an Escherichia coli-produced 9-valent HPV vaccine in adolescents aged 9 to 17 compared with young women |
| Journal | Science Bulletin; |
| Authors | Yulin Jing, Xiaowen Hu, Li Zhang, Jiangyahui Wang, Fei Yang, Rong Wang, Ying Jiang, Lingling Nie, Zhongqiang Jin, Xuecheng Liu, Sihai Li, Chao Du, Pengjuan Wang, Kun Li, Qi Chen, Shoujie Huang, Zhaofeng Bi, Qiufen Zhang, Weijin Huang, Yingying Su, Ting Wu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1016/j.scib.2026.02.035 |
| DATE | August 26, 2025 |
| Title | Immunogenicity comparison of an Escherichia coli-produced 9-valent human papillomavirus vaccine and Gardasil9 in Chinese women aged 18–26 years: three-year follow-up data from a randomised clinical trial |
| Journal | The Lancet Regional Health – Western Pacific, 2025; 62 |
| Authors | Guo-Hua Zhong, Zhao-Feng Bi, Kai Chu, Li Zhang, Lu Chen, Kong-Xin Zhu, Jia-Li Quan, Chu Nie, Qi Chen, Ling-Xian Qiu, Jin-Bo Xu, Jia-Xue Li, Ming-Lei Zhang, Sheng Liu, Ling-Ling Nie, Kun Li, Ying-Ying Su, Shou-Jie Huang, Qiu-Fen Zhang, Wei-Jin Huang, Hong-Xing Pan, Ting Wu, Jun Zhang, and Ning-Shao Xia |
| DOI | https://doi.org/10.1016/j.lanwpc.2025.101671 |
| DATE | October 30, 2023 |
| Title | Immunogenicity and safety of an Escherichia coli-produced human papillomavirus (types 6/11/16/18/31/33/45/52/58) L1 virus-like-particle vaccine: a phase 2 double-blind, randomized, controlled trial |
| Journal | Science Bulletin, Volume 68, Issue 20 |
| Authors | Yue-Mei Hu, Zhao-Feng Bi, Ya Zheng, Li Zhang, Feng-Zhu Zheng, Kai Chu, Ya-Fei Li, Qi Chen, Jia-Li Quan, Xiao-Wen Hu, Xing-Cheng Huang, Kong-Xin Zhu, Ya-Hui Wang-Jiang, Han-Min Jiang, Xia Zang, Dong-Lin Liu, Chang-Lin Yang, Hong-Xing Pan, Qiu-Fen Zhang, Ying-Ying Su, Shou-Jie Huang, Guang Sun, Wei-Jin Huang, Yue Huang, Ting Wu, Jun Zhang, Ning-Shao Xia |
| DOI | https://doi.org/10.1016/j.scib.2023.09.020 |
| DATE | July 17, 2023 |
| Title | Head-to-head immunogenicity comparison of an Escherichia coli-produced 9-valent human papillomavirus vaccine and Gardasil 9 in women aged 18–26 years in China: a randomised blinded clinical trial |
| Journal | The Lancet Infectious Diseases, 2023; 23, 1313-1322 |
| Authors | Feng-Cai Zhu, Guo-Hua Zhong, Wei-Jin Huang, Kai Chu, Li Zhang, Zhao-Feng Bi, Kong-Xin Zhu, Qi Chen, Ting-Quan Zheng, Ming-Lei Zhang, Sheng Liu, Jin-Bo Xu, Hong-Xing Pan, Guang Sun, Feng-Zhu Zheng, Qiu-Fen Zhang, Xiu-Mei Yi, Si-Jie Zhuang, Shou-Jie Huang, Hui-Rong Pan, Ying-Ying Su, Ting Wu, Jun Zhang, Ning-Shao Xia |
| DOI | https://doi.org/10.1016/S1473-3099(23)00275-X |
| DATE | March 12, 2023 |
| Title | Safety and immunogenicity of an Escherichia coli-produced 9-valent human papillomavirus L1 virus-like particle vaccine (types 6/11/16/18/31/33/45/52/58) in healthy adults: an open-label, dose-escalation phase 1 clinical trial |
| Journal | The Lancet Regional Health – Western Pacific, 2023; 34 |
| Authors | Kai Chu, Zhao-Feng Bi, Wei-Jin Huang, Ya-Fei Li, Li Zhang, Chang-Lin Yang, Han-Min Jiang, Xia Zang, Qi Chen, Dong-Lin Liu, Hong-Xing Pan, Yue Huang, Feng-Zhu Zheng, Qiu-Fen Zhang, Guang Sun, Ying-Ying Su, Shou-Jie Huang, Hui-Rong Pan, Ting Wu, Yue-Mei Hu, Jun Zhang, Feng-Cai Zhu, and Ning-Shao Xia |
| DOI | https://doi.org/10.1016/j.lanwpc.2023.100731 |
| DATE | May 29, 2026 |
| Title | Immunogenicity and safety of co-administered Escherichia coli-produced bivalent HPV-16/18 vaccine and hepatitis E vaccine |
| Journal | Frontiers in Immunology, 2026; 17:1837539 |
| Authors | Rui Yan, Mengting Cen, Yang Zhou, Liyang Ma, Xiaofei Zhou, Hanqing He, Xiaohua Qi, Xuewen Tang, Hui Liang, Yaping Chen, Jiaxing Qi, Shigui Yang |
| DOI | https://doi.org/10.3389/fimmu.2026.1837539 |
| DATE | May 20, 2026 |
| Title | Memory Cell and Antibody Responses Following a Single Versus Two Doses of Escherichia coli-Produced Vaccine Against Human Papillomavirus Types 16 and 18: A Real-World Study in Chinese Girls |
| Journal | International Journal of Cancer, 2026; 0:1–13 |
| Authors | Tianmeng Wen, Li Dong, Jiayi Li, Yushu Feng, Lingling Nie, Zhongliang Li, Li Zhang, Shangying Hu, Weijin Huang, Fanghui Zhao, Partha Basu |
| DOI | https://doi.org/10.1002/ijc.70553 |
| DATE | January 14, 2026 |
| Title | Variations in the Natural History of High-Risk HPV Types Following HPV-16/18 Bivalent Vaccination in Females Aged 18-45 Years |
| Journal | Nature Communications, 2026; 17:1677 |
| Authors | Qi Chen, Jiali Quan, Kongxin Zhu, Linchen Lan, Jiaoxi Lu, Linfeng Zhu, Bin Zhang, Guohua Zhong, Zhaofeng Bi, Shoujie Huang, Yingying Su, Lihui Wei, Youlin Qiao, Jun Zhang, Ting Wu, Ningshao Xia |
| DOI | https://doi.org/10.1038/s41467-026-68379-3 |
| DATE | December 1, 2025 |
| Title | Immunopersistence of one or two doses of an Escherichia coli produced bivalent HPV vaccine |
| Journal | npj Vaccines, 2026; 11:16 |
| Authors | Mengjun Liao, Jiali Quan, Kongxin Zhu, Xiaowen Hu, Shudan Shen, Jianhua Xu, Chu Nie, Weizhuo Xu, Hexuan Jiang, Xianliang Wu, Yanqin Zhong, Yuhang Peng, Shihui Cai, Jie Chen, Chengzong Zhang, Bizhen Lin, Yingying Su, Shoujie Huang, Qi Chen, Ting Wu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1038/s41541-025-01335-2 |
| DATE | August 21, 2025 |
| Title | Long-term efficacy and immunopersistence of an Escherichia coli-produced HPV-16/18 bivalent vaccine: an observational extension study following a randomised, double-blind Phase III clinical trial cohort |
| Journal | The Lancet Regional Health – Western Pacific, 2025; 61:101668 |
| Authors | Fanghui Zhao, Qi Chen, Chao Zhao, Lingling Nie, Shangying Hu, Jian Yin, Lingxian Qiu, Zhaofeng Bi, Jiali Quan, Yufei Li, Mingzhu Li, Xun Zhang, Qinjing Pan, Caihong Li, Lidong Ke, Xiaoli Liu, Fengxian Zheng, Cuihong Dai, Zhe Wang, Xuefeng Kuang, Xinhua Jia, Yingying Su, Shoujie Huang, Qiufen Zhang, Weijin Huang, Lihui Wei, Jun Zhang, Ting Wu, Youlin Qiao, Ningshao Xia |
| DOI | https://doi.org/10.1016/j.lanwpc.2025.101668 |
| DATE | March 21, 2025 |
| Title | Head-to-head immunogenicity comparison of one-dose Cecolin and Gardasil in Chinese girls aged 9–14 years: A randomized and open-label clinical trial |
| Journal | Vaccine, 2025; 55:127015 |
| Authors | Fangqin Xie, Kaili Du, Junrong Li, Sumei Zhong, Chun Fan, Zhaofeng Bi, Qiufen Zhang, Jiandong Chen, Shanshan Ma, Dongjuan Zhang |
| DOI | https://doi.org/10.1016/j.vaccine.2025.127015 |
| DATE | March 19, 2025 |
| Title | Immunogenicity and safety of an Escherichia coli-produced bivalent human papillomavirus vaccine (Cecolin) in girls aged 9–14 years in Ghana and Bangladesh: a randomised, controlled, open-label, non-inferiority, phase 3 trial |
| Journal | The Lancet Infectious Diseases, 2025; 25:861–872 |
| Authors | Tsiri Agbenyega, Anne E Schuind, Samuel Adjei, Kalpana Antony, John J Aponte, Patrick B Y Buabeng, John D Clemens, Lokman Hossain, Troy J Kemp, Laina D Mercer, Ligia A Pinto, Firdausi Qadri, Kristen Sukraw, Niranjan Bhat, Khalequ Zaman |
| DOI | https://doi.org/10.1016/S1473-3099(25)00031-3 |
| DATE | January 10, 2025 |
| Title | Long-term protective efficacy of the Escherichia coli-produced HPV-16/18 bivalent human papillomavirus vaccine in women vaccinated at 18–45 years: A 9-year follow-up study |
| Journal | Infectious Medicine, 2025; 4(1):100164 |
| Authors | Xinhua Jia, Shangying Hu, Xuefeng Kuang, Youlin Qiao |
| DOI | https://doi.org/10.1016/j.imj.2025.100164 |
| DATE | April 2, 2024 |
| Title | Safety and immunogenicity of Innovax bivalent human papillomavirus vaccine in girls 9–14 years of age: Interim analysis from a phase 3 clinical trial |
| Journal | Vaccine, 2024; 42(9):2290–2298 |
| Authors | Khalequ Zaman, Anne E Schuind, Samuel Adjei, Kalpana Antony, John J Aponte, Patrick B Y Buabeng, Firdausi Qadri, Troy J Kemp, Lokman Hossain, Ligia A Pinto, Kristen Sukraw, Niranjan Bhat, Tsiri Agbenyega |
| DOI | https://doi.org/10.1016/j.vaccine.2024.02.077 |
| DATE | March 15, 2023 |
| Title | Safety of hepatitis E vaccination for pregnancy: a post-hoc analysis of a randomized, double-blind, controlled phase 3 clinical trial |
| Journal | Emerging Microbes & Infections, 2023; 12: 2185456 |
| Authors | Guohua Zhong, Chunlan Zhuang, Xiaowen Hu, Qi Chen, Zhaofeng Bi, Xinhua Jia, Siying Peng, Yufei Li, Yue Huang, Qiufen Zhang, Ying Hong, Youlin Qiao, Yingying Su, Huirong Pan, Ting Wu, Lihui Wei, Shoujie Huang, Jun Zhang, and Ningshao Xia |
| DOI | https://doi.org/10.1080/22221751.2023.2185456 |
| DATE | August 26, 2022 |
| Title | Efficacy, safety, and immunogenicity of an Escherichia coli-produced human papillomavirus (16 and 18) L1 virus-like-particle vaccine: end-of-study analysis of a phase 3, double-blind, randomised, controlled trial |
| Journal | The Lancet Infectious Diseases, 2022; 22:1756–1768 |
| Authors | Fang-Hui Zhao, Ting Wu, Yue-Mei Hu, Li-Hui Wei, Ming-Qiang Li, Wei-Jin Huang, Wen Chen, Shou-Jie Huang, Qin-Jing Pan, Xun Zhang, Ying Hong, Chao Zhao, Qing Li, Kai Chu, Yun-Fei Jiang, Ming-Zhu Li, Jie Tang, Cai-Hong Li, Dong-Ping Guo, Li-Dong Ke, Xin Wu, Xing-Mei Yao, Jian-Hui Nie, Bi-Zhen Lin, Yu-Qian Zhao, Meng Guo, Jun Zhao, Feng-Zhu Zheng, Xiao-Qian Xu, Ying-Ying Su, Qiu-Fen Zhang, Guang Sun, Feng-Cai Zhu, Shao-Wei Li, Yi-Min Li, Hui-Rong Pan, Jun Zhang, You-Lin Qiao, Ningshao Xia |
| DOI | https://doi.org/10.1016/S1473-3099(22)00435-2 |
| DATE | July 29, 2022 |
| Title | Comparison of HPV-neutralizing and IgG antibodies in unvaccinated female adolescents |
| Journal | Future Microbiology, 2022; 17(15):1207–1215 |
| Authors | Xingmei Yao, Kai Chu, Jun Zhao, Yuemei Hu, Zhijie Lin, Bizhen Lin, Qi Chen, Yafei Li, Qiufen Zhang, Mujin Fang, Shoujie Huang, Yingbin Wang, Yingying Su, Ting Wu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.2217/fmb-2021-0221 |
| DATE | April 13, 2022 |
| Title | Long-term immunopersistence and safety of the Escherichia coli-produced HPV-16/18 bivalent vaccine in Chinese adolescent girls |
| Journal | Human Vaccines & Immunotherapeutics, 2022; 18(5) |
| Authors | Xingmei Yao, Wengang He, Xianghong Wu, Jianxiang Gu, Jing Zhang, Bizhen Lin, Zhaofeng Bi, Yingying Su, Shoujie Huang, Yuemei Hu, Ting Wu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1080/21645515.2022.2061248 |
| DATE | July 16, 2021 |
| Title | Naturally acquired HPV antibodies against subsequent homotypic infection: A large-scale prospective cohort study |
| Journal | The Lancet Regional Health – Western Pacific, 2021; 13:100196 |
| Authors | Xingmei Yao, Wen Chen, Chao Zhao, Lihui Wei, Yuemei Hu, Mingqiang Li, Zhijie Lin, Bizhen Lin, Xiaohui Liu, Ying Hong, Qing Li, Qinjing Pan, Xun Zhang, Mingzhu Li, Yuqian Zhao, Li Zhang, Huifang Xu, Fangfang Hu, Jun Zhao, Yue Huang, Wei Sheng, Ya Zheng, Shangying Hu, Yingying Su, Shoujie Huang, Huirong Pan, Fanghui Zhao, Youlin Qiao, Ting Wu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1016/j.lanwpc.2021.100196 |
| DATE | March 1, 2021 |
| Title | Inflammation-related adverse reactions following vaccination potentially indicate a stronger immune response |
| Journal | Emerging Microbes & Infections, 2021; 10(1):365–375 |
| Authors | Chun-Lan Zhuang, Zhi-Jie Lin, Zhao-Feng Bi, Ling-Xian Qiu, Fang-Fang Hu, Xiao-Hui Liu, Bi-Zhen Lin, Ying-Ying Su, Hui-Rong Pan, Tian-Ying Zhang, Shou-Jie Huang, Yue-Mei Hu, You-Lin Qiao, Feng-Cai Zhu, Ting Wu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1080/22221751.2021.1891002 |
| DATE | July 24, 2020 |
| Title | Comparing immunogenicity of the Escherichia coli-produced bivalent human papillomavirus vaccine in females of different ages |
| Journal | Vaccine, 2020; 38:6096–6102 |
| Authors | Qi Chen, Hui Zhao, Xingmei Yao, Zhijie Lin, Juan Li, Bizhen Lin, Rui Wang, Yue Huang, Yingying Su, Ting Wu, Changgui Li, Huirong Pan, Shoujie Huang, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1016/j.vaccine.2020.07.030 |
| DATE | June 16, 2020 |
| Title | Immunogenicity of an Escherichia coli-produced bivalent human papillomavirus vaccine under different vaccination intervals |
| Journal | Human Vaccines & Immunotherapeutics, 2020 |
| Authors | Xiao-Juan Yu, Juan Li, Zhi-Jie Lin, Hui Zhao, Bi-Zhen Lin, You-Lin Qiao, Yue-Mei Hu, Li-Hui Wei, Rong-Cheng Li, Wei-Dan Huang, Ting Wu, Shou-Jie Huang, Chang-Gui Li, Hui-Rong Pan, Jun Zhang |
| DOI | https://doi.org/10.1080/21645515.2020.1761202 |
| DATE | January 3, 2020 |
| Title | Age distribution of human papillomavirus infection and neutralizing antibodies in healthy Chinese women aged 18–45 years enrolled in a clinical trial |
| Journal | Clinical Microbiology and Infection, 2020; 26:1069–1075 |
| Authors | Lihui Wei, Ying-Ying Su, Yuemei Hu, Rong-Cheng Li, Wen Chen, Qinjing Pan, Xun Zhang, Fang-Hui Zhao, Yu-Qian Zhao, Qing Li, Ying Hong, Chao Zhao, Ming-Qiang Li, Wen-Yu Liu, Cai-Hong Li, Dong-Ping Guo, Li-Dong Ke, Bi-Zhen Lin, Zhi-Jie Lin, Si Chen, Wei Sheng, Zi-Zheng Zheng, Si-Jie Zhuang, Feng-Cai Zhu, Hui-Rong Pan, Yi-Min Li, Shou-Jie Huang, Jun Zhang, You-Lin Qiao, Ting Wu, Ningshao Xia |
| DOI | https://doi.org/10.1016/j.cmi.2019.12.010 |
| DATE | November 26, 2019 |
| Title | Lot-to-lot consistency study of an Escherichia coli-produced bivalent human papillomavirus vaccine in adult women: a randomized trial |
| Journal | Human Vaccines & Immunotherapeutics, 2020; 16(7):1636–1644 |
| Authors | Ying-Ying Su, Bi-Zhen Lin, Hui Zhao, Juan Li, Zhi-Jie Lin, You-Lin Qiao, Li-Hui Wei, Yue-Mei Hu, Rong-Cheng Li, Si-Jie Zhuang, Guang Sun, Zi-Zheng Zheng, Shou-Jie Huang, Ting Wu, Jun Zhang, Hui-Rong Pan, Chang-Gui Li |
| DOI | https://doi.org/10.1080/21645515.2019.1691413 |
| DATE | June 21, 2019 |
| Title | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs. 3 doses in young women |
| Journal | Science China Life Sciences, 2020; 63:582–591 |
| Authors | Yue-Mei Hu, Meng Guo, Chang-Gui Li, Kai Chu, Wen-Gang He, Jing Zhang, Jian-Xiang Gu, Juan Li, Hui Zhao, Xiang-Hong Wu, Bi-Zhen Lin, Zhi-Jie Lin, Xing-Mei Yao, Ya-Fei Li, Fei-Xue Wei, Yue Huang, Ying-Ying Su, Feng-Cai Zhu, Shou-Jie Huang, Hui-Rong Pan, Ting Wu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1007/s11427-019-9547-7 |
| DATE | May 14, 2019 |
| Title | Efficacy, safety, and immunogenicity of an Escherichia coli-produced bivalent human papillomavirus vaccine: An interim analysis of a randomized clinical trial |
| Journal | Journal of the National Cancer Institute, 2020; 112(2):djz074 |
| Authors | You-Lin Qiao, Ting Wu, Rong-Cheng Li, Yue-Mei Hu, Li-Hui Wei, Chang-Gui Li, Wen Chen, Shou-Jie Huang, Fang-Hui Zhao, Ming-Qiang Li, Qin-Jing Pan, Xun Zhang, Qing Li, Ying Hong, Chao Zhao, Wen-Hua Zhang, Yan-Ping Li, Kai Chu, Mei Li, Yun-Fei Jiang, Juan Li, Hui Zhao, Zhi-Jie Lin, Xue-Lian Cui, Wen-Yu Liu, Cai-Hong Li, Dong-Ping Guo, Li-Dong Ke, Xin Wu, Jie Tang, Guo-Qi Gao, Ba-Yi Li, Bin Zhao, Feng-Xian Zheng, Cui-Hong Dai, Meng Guo, Jun Zhao, Ying-Ying Su, Jun-Zhi Wang, Feng-Cai Zhu, Shao-Wei Li, Hui-Rong Pan, Yi-Min Li, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1093/jnci/djz074 |
| DATE | July 31, 2015 |
| Title | Immunogenicity and safety of an E. coli-produced bivalent human papillomavirus (type 16 and 18) vaccine: A randomized controlled phase 2 clinical trial |
| Journal | Vaccine, 2015; 33(32):3940–3946 |
| Authors | Ting Wu, Yue-Mei Hu, Juan Li, Kai Chu, Shou-Jie Huang, Hui Zhao, Zhong-Ze Wang, Chang-Lin Yang, Han-Min Jiang, Yi-Jun Wang, Zhi-Jie Lin, Hui-Rong Pan, Wei Sheng, Fei-Xue Wei, Shao-Wei Li, Ying Wang, Feng-Cai Zhu, Chang-Gui Li, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.1016/j.vaccine.2015.06.052 |
| DATE | October 25, 2013 |
| Title | Safety of an Escherichia coli-expressed bivalent human papillomavirus (types 16 and 18) L1 virus-like particle vaccine: An open-label phase I clinical trial |
| Journal | Human Vaccines & Immunotherapeutics, 2014; 10(2):469–475 |
| Authors | Yue-Mei Hu, Shou-Jie Huang, Kai Chu, Ting Wu, Zhong-Ze Wang, Chang-Lin Yang, Jia-Ping Cai, Han-Min Jiang, Yi-Jun Wang, Meng Guo, Xiao-Hui Liu, Hong-Jiang Huang, Feng-Cai Zhu, Jun Zhang, Ningshao Xia |
| DOI | https://doi.org/10.4161/hv.26846 |
| DATE | May 29, 2026 |
| Title | Immunogenicity and safety of co-administered Escherichia coli-produced bivalent HPV-16/18 vaccine and hepatitis E vaccine |
| Journal | Frontiers in Immunology, 2026; 17:1837539 |
| Authors | Rui Yan, Mengting Cen, Yang Zhou, Liyang Ma, Xiaofei Zhou, Hanqing He, Xiaohua Qi, Xuewen Tang, Hui Liang, Yaping Chen, Jiaxing Qi, Shigui Yang |
| DOI | https://doi.org/10.3389/fimmu.2026.1837539 |
| DATE | December 17, 2025 |
| Title | Long-term protection from naturally acquired immunity against hepatitis E virus reinfection |
| Journal | Nature Communications, 2025; 16: 11187 |
| Authors | Xiaohui Liu, Xia Zang, Kongxin Zhu, Xingcheng Huang, Xiaowen Hu, Zhaofeng Bi, Qi Chen, Hanmin Jiang, Yijun Wang, Changlin Yang, Donglin Liu, Wenhua Zhu, Zizheng Zheng, Yingying Su, Ting Wu, Shoujie Huang, Chunlan Zhuang, Jun Zhang, and Ningshao Xia |
| DOI | https://doi.org/10.1038/s41467-025-66188-8 |
| DATE | July 20, 2025 |
| Title | Safety and immunogenicity of thiomersal-free recombinant hepatitis E vaccine: A randomized, double-blind, active-controlled study |
| Journal | Vaccine, 2025; 62: 127510 |
| Authors | Junrong Li, Xiujuan Wang, Dengxiang Zhang, Fangqin Xie, Sumei Zhong, Xiaoshan Yu, Shasha Chen, Qinbiao Huang, Rui Wang, Qiufen Zhang, and Dongjuan Zhang |
| DOI | https://doi.org/10.1016/j.vaccine.2025.127510 |
| DATE | March 6, 2025 |
| Title | High confidence and demand for hepatitis E vaccine during an outbreak in Bentiu, South Sudan: A qualitative study |
| Journal | PLOS Global Public Health, 2025; 5(3): e0003482 |
| Authors | Aybüke Koyuncu, Kinya Vincent Asilaza, John Rumunu, Joseph Wamala, Priscillah Gitahi, Zelie Antier, Jetske Duncker, Patrick Nkemenang, Primitive Gakima, Melat Haile, Etienne Gignoux, Manuel Albela, Frederick Beden Loro, Duol Biem, Monica Rull, Andrew S. Azman, Iza Ciglenecki, and Robin Nesbitt |
| DOI | https://doi.org/10.1371/journal.pgph.0003482 |
| DATE | February 22, 2025 |
| Title | Safety and immunogenicity of hepatitis E vaccine in compensated liver cirrhosis with chronic hepatitis B |
| Journal | Clinical Microbiology and Infection, Corrected proof |
| Authors | Xuejiao Liao, Dapeng Li, Yingying Su, Xinwu Wang, Shuting Wu, Yanling Chen, Zhiyu Li, Qiyuan Tang, Zhenghua Ma, Xiaobin Wan, Jingke Dong, Liping Zhang, Changxiang Lai, Haiyan Wang, Qing He, Jun Zhang, Fang Wang, and Zheng Zhang |
| DOI | https://doi.org/10.1016/j.cmi.2025.02.027 |
| DATE | February 19, 2025 |
| Title | Effectiveness of a hepatitis E vaccine against medically-attended symptomatic infection in HBsAg-positive adults from a test-negative design study |
| Journal | Nature Communications, 2025; 16: 1699 |
| Authors | Chunlan Zhuang, Xiaohui Liu, Xingcheng Huang, Jiaoxi Lu, Kongxin Zhu, Mengjun Liao, Lu Chen, Hanmin Jiang, Xia Zang, Yijun Wang, Changlin Yang, Donglin Liu, Zizheng Zheng, Xuefeng Zhang, Shoujie Huang, Yue Huang, Yingying Su, Ting Wu, Jun Zhang, and Ningshao Xia |
| DOI | https://doi.org/10.1038/s41467-025-57021-3 |
| DATE | January 10, 2025 |
| Title | Immunogenicity and safety of HepE Hecolin® in chronic hepatitis B patients at clinically stable stage: An open-label study in China |
| Journal | Human Vaccines & Immunotherapeutics, 2025; 21(1): 2448882 |
| Authors | Li Zhang, Qiufen Zhang, Jiaye Liu, Wenlong Wu, Zechun Jiang, Bingyu Yan, Qingfan Cao, Haidong Liu, Huirong Pan, Jingjing Lv, Yi Feng, Fujie Xu, Shoujie Huang, and Aiqiang Xu |
| DOI | https://doi.org/10.1080/21645515.2024.2448882 |
| DATE | January 8, 2025 |
| Title | The effectiveness of two doses of recombinant hepatitis E vaccine in response to an outbreak in Bentiu, South Sudan: a case–control and bias indicator study |
| Journal | The Lancet Infectious Diseases, 2025; 25: 537–547 |
| Authors | Robin C Nesbitt, Vincent Kinya Asilaza, Catia Alvarez, Priscillah Gitahi, Patrick Nkemenang, Jetske Duncker, Melat Haile, Primitive Gakima, Joseph F Wamala, Fredrick Beden Loro, Aybüke Koyuncu, Duol Biem, Manuel Albela, Monica Rull, Etienne Gignoux, John Rumunu, Isabella Eckerle, Iza Ciglenecki, and Andrew S Azman |
| DOI | https://doi.org/10.1016/S1473-3099(24)00657-1 |
| DATE | December 31, 2024 |
| Title | Immunogenicity, Efficacy, and Effectiveness of Two-Dose and Shorter Schedules of Hepatitis E Vaccine: A Systematic Review |
| Journal | Vaccines, 2025; 13: 28 |
| Authors | Bilal Azam, Melanie Marti, Amit Goel, and Rakesh Aggarwal |
| DOI | https://doi.org/10.3390/vaccines13010028 |
| DATE | December 19, 2024 |
| Title | Persistence of hepatitis E vaccine-induced antibody response across different dosage schedules and baseline serostatus |
| Journal | npj Vaccines, 2024; 9: 245 |
| Authors | Kongxin Zhu, Mengjun Liao, Lu Chen, Jiaoxi Lu, Xingcheng Huang, Chunlan Zhuang, Yingying Su, Shoujie Huang, Ting Wu, Jun Zhang, and Ningshao Xia |
| DOI | https://doi.org/10.1038/s41541-024-01041-5 |
| DATE | November, 2024 |
| Title | Safety of hepatitis E vaccine in pregnancy: an emulated target trial following a mass reactive vaccination campaign in Bentiu internally displaced persons camp, South Sudan |
| Journal | The Lancet Global Health, 2024; 12: e1881–e1890 |
| Authors | Robin C Nesbitt, Andrew S Azman, Vincent Kinya Asilaza, Jessie K Edwards, Priscillah Gitahi, Patrick Nkemenang, Jetske Duncker, Melat Haile, Primitive Gakima, Joseph F Wamala, Fredrick Beden Loro, Duol Biem, Nelly Staderini, Manuel Albela, Monica Rull, John Rumunu, Iza Ciglenecki, and Etienne Gignoux |
| DOI | https://doi.org/10.1016/S2214-109X(24)00321-8 |
| DATE | August, 2024 |
| Title | Safety and effectiveness of a recombinant hepatitis E vaccine in women of childbearing age in rural Bangladesh: a phase 4, double-blind, cluster-randomised, controlled trial |
| Journal | The Lancet Global Health, 2024; 12: e1288–e1299 |
| Authors | Khalequ Zaman, Cathinka Halle Julin, Asma Binte Aziz, Kathrine Stene-Johansen, Md Yunus, Firdausi Qadri, Emily S Gurley, Synne Sandbu, Joakim Øverbø, Jennifer L Dembinski, Ida Laake, Taufiqur R Bhuiyan, Mustafizur Rahman, Warda Haque, Mahbuba Khanam, John D Clemens, and Susanne Dudman |
| DOI | https://doi.org/10.1016/S2214-109X(24)00192-X |
| DATE | August, 2024 |
| Title | Receipt of hepatitis E vaccine and fetal loss in rural Bangladesh: further analysis of a double-blind, cluster-randomised, controlled trial |
| Journal | The Lancet Global Health, 2024; 12: e1300–e1311 |
| Authors | Asma Binte Aziz, Susanne Dudman, Cathinka Halle Julin, Faisal Ahmmed, Kathrine Stene-Johansen, Synne Sandbu, Joakim Øverbø, Jennifer L Dembinski, Torbjørn Wisløff, Sohel Rana, Ahsan-ul Habib Basunia, Warda Haque, Firdausi Qadri, Khalequ Zaman, and John D Clemens |
| DOI | https://doi.org/10.1016/S2214-109X(24)00193-1 |
| DATE | March 27, 2024 |
| Title | A Phase 1, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of HEV-239 (Hecolin) Vaccine in Healthy US Adults |
| Journal | The Journal of Infectious Diseases, 2024; 230: 1093–1101 |
| Authors | Carol M. Kao, Christina A. Rostad, Lauren E. Nolan, Etza Peters, Jennifer Kleinhenz, Jacob D. Sherman, Ashley Tippett, J. Wai Kuo Shih, Inci Yildirim, Vivien Agbakoba, Tatiana Beresnev, Cassandra Ballou, Satoshi Kamidani, Vinit Karmali, Muktha Natrajan, Erin M. Scherer, Nadine Rouphael, and Evan J. Anderson |
| DOI | https://doi.org/10.1093/infdis/jiae148 |
| DATE | February 19, 2024 |
| Title | Long-term efficacy of a recombinant hepatitis E vaccine in adults: 10-year results from a randomised, double-blind, placebo-controlled, phase 3 trial |
| Journal | The Lancet, 2024; published online |
| Authors | Shoujie Huang, Xuefeng Zhang, Yingying Su, Chunlan Zhuang, Zimin Tang, Xingcheng Huang, Qi Chen, Kongxin Zhu, Xiaowen Hu, Ying Dong, Xiaohui Liu, Hanmin Jiang, Xia Zang, Zhongze Wang, Changlin Yang, Donglin Liu, Yijun Wang, Quan Tang, Wendong Shen, Huanhuan Cao, Huirong Pan, Shengxiang Ge, Yue Huang, Ting Wu, Zizheng Zheng, Fengcai Zhu, Jun Zhang, and Ningshao Xia |
| DOI | https://doi.org/10.1016/S0140-6736(23)02234-1 |
| DATE | January 22, 2024 |
| Title | Vaccination coverage and adverse events following a reactive vaccination campaign against hepatitis E in Bentiu displaced persons camp, South Sudan |
| Journal | PLOS Neglected Tropical Diseases, 2024; 18(1): e0011661 |
| Authors | Robin C. Nesbitt, Vincent Kinya Asilaza, Etienne Gignoux, Aybüke Koyuncu, Priscillah Gitahi, Patrick Nkemenang, Jetske Duncker, Zelie Antier, Melat Haile, Primitive Gakima, Joseph F. Wamala, Fredrick Beden Loro, Duol Biem, Monica Rull, Andrew S. Azman, John Rumunu, and Iza Ciglenecki |
| DOI | https://doi.org/10.1371/journal.pntd.0011661 |
| DATE | March 15, 2023 |
| Title | Safety of hepatitis E vaccination for pregnancy: a post-hoc analysis of a randomized, double-blind, controlled phase 3 clinical trial |
| Journal | Emerging Microbes & Infections, 2023; 12: 2185456 |
| Authors | Guohua Zhong, Chunlan Zhuang, Xiaowen Hu, Qi Chen, Zhaofeng Bi, Xinhua Jia, Siying Peng, Yufei Li, Yue Huang, Qiufen Zhang, Ying Hong, Youlin Qiao, Yingying Su, Huirong Pan, Ting Wu, Lihui Wei, Shoujie Huang, Jun Zhang, and Ningshao Xia |
| DOI | https://doi.org/10.1080/22221751.2023.2185456 |
| DATE | December 28, 2022 |
| Title | Immunogenicity and safety of a two-dose regimen with hepatitis E virus vaccine in healthy adults in rural Bangladesh: A randomized, double-blind, controlled, phase 2/pilot trial |
| Journal | Vaccine, Corrected proof |
| Authors | Joakim Øverbø, Asma Aziz, K Zaman, John Clemens, Cathinka Halle Julin, Firdausi Qadri, Kathrine Stene-Johansen, Rajib Biswas, Shaumik Islam, Taufiqur Rahman Bhuiyan, Warda Haque, Synne Sandbu, Manzoor E Elahee, Mohammad Ali, Jennifer L Dembinski, and Susanne Dudman |
| DOI | https://doi.org/10.1016/j.vaccine.2022.12.064 |
| DATE | December, 2022 |
| Title | Consistency of safety and immunogenicity of three consecutive batches of hepatitis E vaccine in healthy people over 18 years of age |
| Journal | Chinese Journal of Biologicals, 2022; 35(12): 1477–1481 |
| Authors | Yu Xiaoshan, Li Xiaohua, Feng Hao, Wei Mingwei, Wang Wenjuan, Liu Donglin, Yang Changlin, Jiang Hanmin, Zhang Qiufen, and Hu Yuemei |
| DOI | https://doi.org/10.13200/j.cnki.cjb.003763 |
| DATE | August, 2022 |
| Title | The first reactive vaccination campaign against hepatitis E |
| Journal | The Lancet Infectious Diseases, 2022; 22: 1110–1111 |
| Authors | Iza Ciglenecki, John Rumunu, Joseph F Wamala, Patrick Nkemenang, Jetske Duncker, Robin Nesbitt, Etienne Gignoux, Trish Newport, Melat Heile, Christine Jamet, Monica Rull, and Andrew S Azman |
| DOI | https://doi.org/10.1016/S1473-3099(22)00421-2 |
| DATE | April 6, 2022 |
| Title | Evaluation of safety and immunogenicity of hepatitis E vaccine in maintenance hemodialysis patients |
| Journal | Chinese Journal of Preventive Medicine, 2022; 56(4): 464–467 |
| Authors | Wang Xuelian, Li Yanting, Ma Xinjing, Ling Yisheng, Wu Ting, and Niu Jianjun |
| DOI | https://doi.org/10.3760/cma.j.cn112150-20220223-00168 |
| DATE | January 19, 2020 |
| Title | HEV study protocol: design of a cluster-randomised, blinded trial to assess the safety, immunogenicity and effectiveness of the hepatitis E vaccine HEV 239 (Hecolin) in women of childbearing age in rural Bangladesh |
| Journal | BMJ Open, 2020; 10: e033702 |
| Authors | K Zaman, Susanne Dudman, Kathrine Stene-Johansen, Firdausi Qadri, Md Yunus, Synne Sandbu, Emily S Gurley, Joakim Øverbø, Cathinka Halle Julin, Jennifer Lynn Dembinski, Quamrun Nahar, Anisur Rahman, Taufiqur R Bhuiyan, Mustafizur Rahman, Warda Haque, Jahangir Khan, Asma Aziz, Mahbuba Khanam, Peter Kim Streatfield, and John D Clemens |
| DOI | https://doi.org/10.1136/bmjopen-2019-033702 |
| DATE | June 28, 2019 |
| Title | Safety and immunogenicity of hepatitis E vaccine in elderly people older than 65 years |
| Journal | Vaccine, 2019; 37: 4581–4586 |
| Authors | Xu-ya Yu, Zhi-ping Chen, Shen-yu Wang, Hui-rong Pan, Zhi-fang Wang, Qiu-fen Zhang, Ling-zhi Shen, Xiao-ping Zheng, Chuan-fu Yan, Mei Lu, Bo Chen, Ya Zheng, Jun Zhang, Hua-kun Lv, and Shou-jie Huang |
| DOI | https://doi.org/10.1016/j.vaccine.2019.04.006 |
| DATE | April 10, 2019 |
| Title | Study on the safety and immunogenicity of simultaneous vaccination on both hepatitis E and hepatitis B vaccines |
| Journal | Chinese Journal of Epidemiology, 2019; 40(4): 451–455 |
| Authors | Ma Jianxin, Liu Yuqiang, Li Qian, Ge Shen, and Zhang Zheng |
| DOI | https://doi.org/10.3760/cma.j.issn.0254-6450.2019.04.015 |
| DATE | January 31, 2019 |
| Title | Immunogenicity and safety of an accelerated hepatitis E vaccination schedule in healthy adults: a randomized, controlled, open-label, phase IV trial |
| Journal | Clinical Microbiology and Infection, 2019; 25: 1133–1139 |
| Authors | Z. Chen, S. Lin, J. Duan, Y. Luo, S. Wang, Z. Gan, H. Yi, T. Wu, S. Huang, Q. Zhang, and H. Lv |
| DOI | https://doi.org/10.1016/j.cmi.2019.01.015 |
| DATE | November 9, 2016 |
| Title | Persistence of antibodies acquired by natural hepatitis E virus infection and effects of vaccination |
| Journal | Clinical Microbiology and Infection, 2017; 23: 336.e1–336.e4 |
| Authors | Y.-Y. Su, S.-J. Huang, M. Guo, J. Zhao, H. Yu, W.-G. He, H.-M. Jiang, Y.-J. Wang, X.-F. Zhang, J.-P. Cai, C.-L. Yang, Z.-Z. Wang, F.-C. Zhu, T. Wu, J. Zhang, and N.-S. Xia |
| DOI | https://doi.org/10.1016/j.cmi.2016.10.029 |
| DATE | June 8, 2015 |
| Title | Modeling the long-term antibody response of a hepatitis E vaccine |
| Journal | Vaccine, 2015; Article in Press |
| Authors | Shu Chen, Zi Zhou, Fei-Xue Wei, Shou-Jie Huang, Zhong Tan, Ya Fang, Feng-Cai Zhu, Ting Wu, Jun Zhang, and Ning-Shao Xia |
| DOI | https://doi.org/10.1016/j.vaccine.2015.06.050 |
| DATE | March 5, 2015 |
| Title | Long-Term Efficacy of a Hepatitis E Vaccine |
| Journal | The New England Journal of Medicine, 2015; 372: 914–922 |
| Authors | Jun Zhang, Xue-Feng Zhang, Shou-Jie Huang, Ting Wu, Yue-Mei Hu, Zhong-Ze Wang, Hua Wang, Han-Min Jiang, Yi-Jun Wang, Qiang Yan, Meng Guo, Xiao-Hui Liu, Jing-Xin Li, Chang-Lin Yang, Quan Tang, Ren-Jie Jiang, Hui-Rong Pan, Yi-Min Li, J. Wai-Kuo Shih, Mun-Hon Ng, Feng-Cai Zhu, and Ning-Shao Xia |
| DOI | https://doi.org/10.1056/NEJMoa1406011 |
| DATE | November 18, 2013 |
| Title | Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity |
| Journal | Clinical Microbiology and Infection, 2014; 20: O397–O405 |
| Authors | J. Zhang, X.-F. Zhang, C. Zhou, Z.-Z. Wang, S.-J. Huang, X. Yao, Z.-L. Liang, T. Wu, J.-X. Li, Q. Yan, C.-L. Yang, H.-M. Jiang, H.-J. Huang, Y.-L. Xian, J. W.-K. Shih, M.-H. Ng, Y.-M. Li, J.-Z. Wang, F.-C. Zhu, and N.-S. Xia |
| DOI | https://doi.org/10.1111/1469-0691.12419 |
| DATE | July 25, 2013 |
| Title | Immunogenicity and safety of hepatitis E vaccine in healthy hepatitis B surface antigen positive adults |
| Journal | Human Vaccines & Immunotherapeutics, 2013; 9(11): 2474–2479 |
| Authors | Ting Wu, Shou-Jie Huang, Feng-Cai Zhu, Xue-Feng Zhang, Xing Ai, Qiang Yan, Zhong-Ze Wang, Chang-Lin Yang, Han-Min Jiang, Xiao-Hui Liu, Meng Guo, Hai-Lian Du, Mun-Hon Ng, Jun Zhang, and Ning-Shao Xia |
| DOI | https://doi.org/10.4161/hv.25814 |
| DATE | June, 2012 |
| Title | Safety of the Hepatitis E Vaccine for Pregnant Women: A Preliminary Analysis |
| Journal | Hepatology, 2012; 56(6): 2038 |
| Authors | Ting Wu, Feng-Cai Zhu, Shou-Jie Huang, Xue-Feng Zhang, Zhong-Ze Wang, Jun Zhang, and Ning-Shao Xia |
| DOI | https://doi.org/10.1002/hep.25522 |
| DATE | August 23, 2010 |
| Title | Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial |
| Journal | The Lancet, 2010; 376: 895–902 |
| Authors | Feng-Cai Zhu, Jun Zhang, Xue-Feng Zhang, Cheng Zhou, Zhong-Ze Wang, Shou-Jie Huang, Hua Wang, Chang-Lin Yang, Han-Min Jiang, Jia-Ping Cai, Yi-Jun Wang, Xing Ai, Yue-Mei Hu, Quan Tang, Xin Yao, Qiang Yan, Yang-Ling Xian, Ting Wu, Yi-Min Li, Ji Miao, Mun-Hon Ng, James Wai-Kuo Shih, and Ning-Shao Xia |
| DOI | https://doi.org/10.1016/S0140-6736(10)61030-6 |
| DATE | January 23, 2009 |
| Title | Randomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccine |
| Journal | Vaccine, 2009; 27: 1869–1874 |
| Authors | Jun Zhang, Chong-bo Liu, Rong-cheng Li, Yi-min Li, Ying-jie Zheng, Yan-ping Li, Dong Luo, Bai-bin Pan, Yi Nong, Sheng-Xiang Ge, Jun-hui Xiong, James Wai-kuo Shih, Mun-Hon Ng, and Ning-shao Xia |
| DOI | https://doi.org/10.1016/j.vaccine.2008.12.061 |
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